Enter the "Options" menu. Select "Cheats", then "Enter New Cheat". Then, enter one of the following codes to unlock the corresponding cheat option. Note: Each note or chord must be strummed during code entry. Press Green at the "Cheats" menu to turn off a particular cheat.
| Code: | Result: |
| Press Yellow + Blue, [Green + Yellow] two times, Green + Yellow, [Red + Blue] two times, [Red + Yellow] two times, Yellow + Blue, [Green + Yellow] two times, [Red + Blue] two times, [Red + Yellow] two times, [Green + Yellow] two times, [Red + Yellow] two times. | Air Guitar |
| Press Yellow + Orange, Red + Blue, Red + Orange, Green + Blue, Red + Yellow, Yellow + Orange, Red + Yellow, Red + Blue, [Green + Yellow] two times, [Yellow + Blue] two times, [Yellow + Orange] two times, Yellow + Blue, Yellow, Red, Red + Yellow, Red, Yellow, Orange. | All songs in Quick Play mode |
| Press Orange, Blue, Orange, Yellow, Orange, Blue, Orange, Yellow. | Hyperspeed mode |
| Press Red + Yellow, Red + Blue, Red + Orange, Red + Blue, Red + Yellow, Green + Blue, Red + Yellow, Red + Blue. | Performance mode |
| Press [Green + Red] three times, [Red + Yellow] two times, [Red + Blue] two times, Yellow + Blue, Yellow + Orange, Yellow + Orange, [Green + Red] three times, [Red + Yellow] two times, [Red + Blue] two times, Yellow + Blue, [Yellow + Orange] two times. | Precision mode |
Complete the indicated task to unlock the corresponding character.
| Unlockable: | How to Unlock: |
| Lou | Successfully complete the game to purchase Lou for $15,000. Lou comes with his skeleton guitar and two costumes (original devil outfit and werewolf viking). |
| Slash | Defeat him in the Boss battle in Career mode to unlock him for purchase at the store for $10,000. |
| Tom Morello | Defeat him in the Boss battle in Career mode to unlock him for purchase at the store for $10,000. |
Complete the indicated task to unlock the corresponding guitar.
| Unlockable: | How to Unlock: |
| "Bat" Guitar | 5-Star Every Song On Easy |
| "Beach Life" Bass | Complete Co-Op Career Mode On Hard |
| "Distant Visitor" Guitar | Complete Career Mode On Expert |
| "El Jefe" Guitar | 5-Star Every Song On Expert |
| "Jolly Roger" Guitar | 5-Star Every Song On Medium |
| "Nemisis 13" Guitar | Complete Co-Op Career Mode On Any Difficulty |
| "Neversoft Skateboard" Guitar | 5-star Co-Op Career Mode On Expert |
| "Rojimbo" Guitar | Complete Career Mode On Hard |
| "Tiki" Guitar | 5-Star Every Song On Hard |
| Moon Shot | Complete the under the Easy difficulty. |
| Saint George | Complete the game under the Medium difficulty. |
To unlock Through The Fire And The Flames by Dragonforce you must beat the whole career mode on any difficulty.
